Article

Identification of epigenome-wide DNA methylation differences between carriers of <i>APOE</i> ε4 and <i>APOE</i> ε2

2019-10-23

Abstract excerpt

<h4>BACKGROUND</h4> The Apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, while the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylation have not previously been characterised. <h4>METHODS</h4> Using the EPIC array, we investigated epige...

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Literature Corpus work: 0ba81e89-a7c4-5c81-b47b-23ce255a03b0
DOI: 10.1101/815035

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