Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study.

Aging cell - 1 Feb 2015

Ma Yiyi, Smith Caren E, Lai Chao-Qiang, Irvin Marguerite R, Parnell Laurence D, Lee Yu-Chi, Pham Lucia, Aslibekyan Stella, Claas Steven A, Tsai Michael Y, Borecki Ingrid B, Kabagambe Edmond K, Berciano Silvia, Ordovás José M, Absher Devin M, Arnett Donna K

Abstract excerpt

Although apolipoprotein E (APOE) variants are associated with age-related diseases, the underlying mechanism is unknown and DNA methylation may be a potential one. With methylation data, measured by the Infinium Human Methylation 450 array, from 993 participants (age ranging from 18 to 87 years) in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study, and from Encyclopedia of DNA Elements (ENCODE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation

Share to Hypolipidemic Agents

Share to Lipids

Share to Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 25476875
DOI: 10.1111/acel.12293
PMCID: PMC4324456

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study.PMID 25476875Read ↗

Identification of epigenome-wide DNA methylation differences between carriers of <i>APOE</i> ε4 and <i>APOE</i> ε2Semantic proximity Read ↗

Apolipoprotein E DNA methylation and late-life diseaseSemantic proximity Read ↗

Haplotype-Resolved DNA Methylation at the <i>APOE</i> Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer’s Disease RiskSemantic proximity Read ↗

<i>APOE</i>Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen ResponseSemantic proximity Read ↗

DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular healthSemantic proximity Read ↗

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.Semantic proximity Read ↗

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.Semantic proximity Read ↗

The APOE Gene is Differentially Methylated in Alzheimer's Disease.Semantic proximity Read ↗

Epigenetic signature and enhancer activity of the human APOE geneSemantic proximity Read ↗

Allelic variation within the major APOE CpG island affects its methylation in the brain of targeted replacement mice expressing human APOE.Semantic proximity Read ↗

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.Semantic proximity Read ↗

Epigenomics of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.