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Haplotype-Resolved DNA Methylation at the <i>APOE</i> Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer’s Disease Risk

2025-07-02

Abstract excerpt

The APOE gene encodes a key lipid transport protein and plays a central role in Alzheimer’s disease (AD) pathogenesis. Three common APOE alleles, ε2 (rs7412(C>T), ε3 (reference), and ε4 (rs429358(T>C)), arise from two coding variants in exon 4 and confer distinct AD risk profiles, with ε4 increasing risk and ε2 providing protection. The ε3-linked APOE variant rs769455[T] has also been associated with elevated A...

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Literature Corpus work
dd80ae6c-5d74-5725-b8b2-7949644113d2
DOI
10.1101/2025.07.01.662592
Open publication

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Haplotype-Resolved DNA Methylation at the <i>APOE</i> Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer’s Disease RiskDOI 10.1101/2025.07.01.662592
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