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<i>APOE</i>missense variant R145C is associated with increased Alzheimer’s disease risk in African ancestry individuals with the<i>APOE ε3/ε4</i>genotype

2021-10-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> The APOE gene has two common missense variants that greatly impact the risk of late-onset Alzheimer’s disease (AD). Here we examined the risk of a third APOE missense variant, R145C, that is rare in European-Americans but present in 4% of African-Americans and always in phase with APOE ε3 . <h4>METHODS</h4> In this study, we included 11,790 individuals of African and Admixed-A...

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Literature Corpus work
96a6bc05-56d5-5fb5-afff-ca46ab3e03f4
DOI
10.1101/2021.10.20.21265141
Open publication

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<i>APOE</i>missense variant R145C is associated with increased Alzheimer’s disease risk in African ancestry individuals with the<i>APOE ε3/ε4</i>genotypeDOI 10.1101/2021.10.20.21265141
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