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Epigenetic signature and enhancer activity of the human APOE gene

25 Jul 2013

Abstract excerpt

The human apolipoprotein E (APOE) gene plays an important role in lipid metabolism. It has three common genetic variants, alleles ε2/ε3/ε4, which translate into three protein isoforms of apoE2, E3 and E4. These isoforms can differentially influence total serum cholesterol levels; therefore, APOE has been linked with cardiovascular disease. Additionally, its ε4 allele is strongly associated with the risk of...

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PMID: 23892237
DOI: 10.1093/hmg/ddt354

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