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Article

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.

Genome medicine - 4 Jan 2021

Walker Rosie M, Vaher Kadi, Bermingham Mairead L, Morris Stewart W, Bretherick Andrew D, Zeng Yanni, Rawlik Konrad, Amador Carmen, Campbell Archie, Haley Chris S, Hayward Caroline, Porteous David J, McIntosh Andrew M, Marioni Riccardo E, Evans Kathryn L

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations with epigenome-wide methylation have not previously been characterised. METHODS: Using the EPIC array, we investigated epigenome-wide differences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33397400
DOI: 10.1186/s13073-020-00808-4
PMCID: PMC7784364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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