Article

Inter- and intra-chromosomal modulators of the <i>APOE</i> ε2 and ε4 effects on the Alzheimer’s disease risk

2022-06-17

Abstract excerpt

The mechanisms of incomplete penetrance of risk modifying impacts of apolipoprotein E ( APOE ) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patterns between 6136 AD-affected and 10555 AD-unaffected subjects from five independent studies to explore whether the association of the APOE ε2 allele (encoded b...

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Literature Corpus work: cba4a4ca-0fa6-57c3-8d99-f01b619f1a66
DOI: 10.1101/2022.06.16.22276523

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