Article

Challenges at the <i>APOE</i> locus: A robust quality control approach for accurate <i>APOE</i> genotyping

2021-10-26

Abstract excerpt

<h4>Background</h4> Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE *2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of APOE pathophysiology and provide critical guidance for AD therapies aimed at APOE . The APOE locus however remains relatively poorly understood in AD, owing to multipl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 024de8b8-dec7-5bb1-838b-22aa86fa4c36
DOI: 10.1101/2021.10.19.21265022

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Challenges at the <i>APOE</i> locus: A robust quality control approach for accurate <i>APOE</i> genotypingDOI 10.1101/2021.10.19.21265022Read

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.Semantic proximity Read

<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s diseaseSemantic proximity Read

<i>APOE</i>missense variant R145C is associated with increased Alzheimer’s disease risk in African ancestry individuals with the<i>APOE ε3/ε4</i>genotypeSemantic proximity Read

Haplotype-Resolved DNA Methylation at the <i>APOE</i> Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer’s Disease RiskSemantic proximity Read

Inter- and intra-chromosomal modulators of the <i>APOE</i> ε2 and ε4 effects on the Alzheimer’s disease riskSemantic proximity Read

Identification of epigenome-wide DNA methylation differences between carriers of <i>APOE</i> ε4 and <i>APOE</i> ε2Semantic proximity Read

Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk.Semantic proximity Read

Phenome-Wide Association of<i>APOE</i>Alleles in the<i>All of Us</i>Research ProgramSemantic proximity Read

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.Semantic proximity Read

<i>APOE</i> *4 Risk-Modifying Genes and Drug Targets in Alzheimer’s Disease through Cell-Type Specific Genomic AnalysesSemantic proximity Read

Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.Semantic proximity Read

Proteomic Signatures of Protected <i>APOE</i> -ε4 Carriers Reveal Causal Pathways Associated with Delayed Alzheimer’s Disease OnsetSemantic proximity Read