Article
Genetic modifiers of APOE-ε4-associated cognitive decline.
Nature communications - 20 Feb 2026
Contreras Alex G, Walters Skylar, Eissman Jaclyn M, Archer Derek B, Regelson Alexandra N, Durant Alaina, Clifton Michelle, Mukherjee Subhabrata, Lee Michael L, Choi Seo-Eun, Scollard Phoebe, Trittschuh Emily H, Mez Jesse, Bush William S, Kunkle Brian W, Cruchaga Carlos, Naj Adam C, Gifford Katherine A, Bilgel Murat, Kuzma Amanda B, Cuccaro Michael L, Pericak-Vance Margaret A, Farrer Lindsay A, Wang Li-San, Schellenberg Gerard D, Haines Jonathan L, Jefferson Angela L, Kukull Walter A, Keene C Dirk, Saykin Andrew J, Thompson Paul M, Martin Eden R, Albert Marilyn S, Johnson Sterling C, Engelman Corinne D, Ferrucci Luigi, Bennett David A, Barnes Lisa L, Schneider Julie A, Sperling Reisa A, Resnick Susan M, Crane Paul K, Dumitrescu Logan, Hohman Timothy J
Abstract excerpt
The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease. However, APOE-ε4 is not deterministic, highlighting the need to identify additional genetic and environmental factors. APOE-ε4 has been linked to accelerated cognitive decline, so we sought to investigate genetic factors that modify APOE-ε4-associated cognitive decline. We conduct cross-ancestry APOE-ε4-stratified and...
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