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Article

Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions.

The Journal of biological chemistry - 1 Oct 2024

Bayati Armin, McPherson Peter S

Abstract excerpt

Research into the pathophysiology of Parkinson's disease (PD) is a fast-paced pursuit, with new findings about PD and other synucleinopathies being made each year. The involvement of various lysosomal proteins, such as TFEB, TMEM175, GBA, and LAMP1/2, marks the rising awareness about the importance of lysosomes in PD and other neurodegenerative disorders. This, along with recent developments regarding the...

Topics

Humans
alpha-Synuclein
Lysosomes
Autophagy
Lewy Bodies
Parkinson Disease
Animals
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39233232
DOI: 10.1016/j.jbc.2024.107742
PMCID: PMC11460475

Genes

LAMP1
TFEB
TMEM175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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