Article

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

2024-04-26

Abstract excerpt

<title>Abstract</title> <p>Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson’s disease. One of the hallmarks of Parkinson’s disease is the aggregation and accumulation of alpha-synuclein into Lewy bodies inside nerve cells. Microglia may worsen the neuronal microenviron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ceb4f30-c5f8-5aa6-a031-07ef6f00b187
DOI: 10.21203/rs.3.rs-4021601/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microgliaDOI 10.21203/rs.3.rs-4021601/v2Read

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.Semantic proximity Read

Parkinson’s disease-derived α-Synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotypeSemantic proximity Read

Immunoregulation of Microglia M2 polarization is an unrecognized physiological function of α -SynucleinSemantic proximity Read

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagySemantic proximity Read

Neuroinflammation and Glial Phenotypic Changes in Alpha-SynucleinopathiesSemantic proximity Read

Alpha-synuclein expression modulates microglial activation phenotype.Semantic proximity Read

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease RiskSemantic proximity Read

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microgliaSemantic proximity Read

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked MutantsSemantic proximity Read

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s diseaseSemantic proximity Read

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.Semantic proximity Read

Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions.Semantic proximity Read