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Article

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.

Glia - 1 Jan 2025

Niskanen Jonna, Peltonen Sanni, Ohtonen Sohvi, Fazaludeen Mohammad Feroze, Luk Kelvin C, Giudice Luca, Koistinaho Jari, Malm Tarja, Goldsteins Gundars, Albert Katrina, Lehtonen Šárka

Abstract excerpt

Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the hallmarks of PD is the aggregation and accumulation of alpha-synuclein (αSyn) into Lewy bodies inside nerve cells. Microglia may worsen the neuronal microenvironment by persistent inflammation,...

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PMID: 39435593
DOI: 10.1002/glia.24626
PMCID: PMC11660540

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