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Article

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy

26 Oct 2022

Abstract excerpt

Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through the lysosome. Although autophagy is highly conserved across all cell types, its activity in each cell is specifically adapted to carry out distinct physiological functions. The role of autophagy in neurons has been well characterized; however, in glial cells, its function remains largely unknown. Microglia are brain-resident...

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PMID: 36288297
DOI: 10.1126/sciadv.abn1298

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