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Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

30 Nov 2016

Abstract excerpt

BACKGROUND: α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson's disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, microglial αSYN clearance is closely related to neuronal survival. Leucine-rich repeat kinase 2 (LRRK2) is the one of the other genes implicated in familial and sporadic...

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PMID: 27903237
DOI: 10.1186/s12868-016-0315-2

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