Article

Internalized α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade α-synuclein fibrils

2024-06-08

Abstract excerpt

Parkinson’s disease (PD) and other α-synucleinopathies are characterized by the intracellular aggregates of α-synuclein (αS) believed to spread via the cell-to-cell transmission. To understand the contributions of various brain cells to the spreading of αS pathology, we examined the metabolism of αS aggregates in neuronal and glial cells. In neurons, while the full-length αS rapidly disappeared following αS PFF up...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97a8e849-b3fc-552c-bb2f-fe45f39a6286
DOI: 10.1101/2024.06.05.597615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Internalized α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade α-synuclein fibrilsDOI 10.1101/2024.06.05.597615Read

Spreading of α-synuclein rewires organelle communication and disrupts neuron-astrocyte mitochondrial quality controlSemantic proximity Read

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.Semantic proximity Read

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microgliaSemantic proximity Read

Potential Modes of Intercellular α-Synuclein TransmissionSemantic proximity Read

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Semantic proximity Read

α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradationSemantic proximity Read

Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo EvidenceSemantic proximity Read

α‐Synuclein fibrils explore actin‐mediated macropinocytosis for cellular entry into model neuroblastoma neuronsSemantic proximity Read

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein ClearanceSemantic proximity Read

Molecular events underlying the cell‐to‐cell transmission of α‐synucleinSemantic proximity Read

Release and uptake of pathologic alpha-synucleinSemantic proximity Read

Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality controlSemantic proximity Read