Article

Calcium directs actin assembly via allosteric activation of formin INF2

2026-01-29

Abstract excerpt

Calcium signals spatiotemporally orchestrate cytoskeletal dynamics, typically through Rho GTPase-mediated signaling cascades, yet the direct molecular transducers that convert local calcium transients into spatially controlled actin assembly have remained elusive. Here, we uncover a structure-based mechanism by which calcium-bound calmodulin (Ca 2+ -CaM) directly activates formin INF2 to drive actin assembly. We...

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Literature Corpus work: 0b2175b3-5deb-5367-966b-c0c868b0567a
DOI: 10.64898/2026.01.27.701936

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