Article

An AI-informed NMR structure reveals a LETM1 F-EF-hand for two-way mitochondrial calcium regulation.

2024-04-27

Abstract excerpt

AlphaFold2 can accurately predict high-resolution protein structure from sequence but does not account for solvent conditions, ligands, post-translational modifications, lowly populated states or rare folds. Human leucine zipper EF-hand transmembrane protein-1 (LETM1) has one sequence-identifiable EF-hand but whether and how calcium (Ca2+) binding affects structure and function remains enigmatic. Here, we develope...

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Literature Corpus work: 35b3c3d9-f7a6-57c7-b0ca-db11730e8cd3
DOI: 10.1101/2024.04.23.590744

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