Article

INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement

2024-07-07

Abstract excerpt

Proper regulation of organelle dynamics is critical for cellular function, but the mechanisms coordinating multiple organelles remain poorly understood. Here we show that actin polymerization mediated by the endoplasmic reticulum (ER)-anchored formin INF2 acts as a master regulator of organelle morphology and movement. Using high-resolution imaging, we demonstrate that INF2-polymerized actin filaments assemble at...

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Literature Corpus work: 07b2413f-0bee-5076-9be7-da19fbc1eb64
DOI: 10.1101/2024.07.06.602365

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