Article

A novel dimeric active site and regulation mechanism revealed by the crystal structure of iPLA <sub>2</sub> β

2017-09-29

Abstract excerpt

Calcium-independent phospholipase A 2 β (iPLA 2 β) regulates several physiological processes including inflammation, calcium homeostasis and apoptosis. It is linked genetically to neurodegenerative disorders including Parkinson’s disease. Despite its known enzymatic activity, the mechanisms underlying pathologic phenotypes remain unknown. Here, we present the first crystal structure of iPLA 2 β that significant...

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Literature Corpus work: aa675fe1-bfc4-5c07-8357-fd4d0efb2e13
DOI: 10.1101/196097

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