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Article

Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.

The Biochemical journal - 15 Jan 2021

Wang Yuning, Tadayon Roya, Santamaria Liliana, Mercier Pascal, Forristal Chantal J, Shaw Gary S

Abstract excerpt

The membrane protein dysferlin (DYSF) is important for calcium-activated plasma membrane repair, especially in muscle fibre cells. Nearly 600 mutations in the DYSF gene have been identified that are causative for rare genetic forms of muscular dystrophy. The dysferlin protein consists of seven C2 domains (C2A-C2G, 13%-33% identity) used to recruit calcium ions and traffic accessory proteins and vesicles to...

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Identifiers

PMID: 33449082
DOI: 10.1042/BCJ20200773

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