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Article

Regulation of the formin INF2 by actin monomers and calcium-calmodulin

2025-10-07

Abstract excerpt

In response to increased intracellular calcium, the formin INF2 polymerizes 20-30% of the total cellular actin pool within 30 sec, suggesting robust regulation. INF2 regulation requires an auto-inhibitory interaction between the N-terminal Diaphanous Inhibitory Domain (DID) and the C-terminal Diaphanous Auto-regulatory Domain (DAD). DID mutations are dominantly linked to two human diseases, and constitutively acti...

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Identifiers and source

Literature Corpus work
c1b00534-663e-562b-82fc-1fa510d2265c
DOI
10.1101/2025.10.06.680766
Open publication

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Regulation of the formin INF2 by actin monomers and calcium-calmodulinDOI 10.1101/2025.10.06.680766
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