Article

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

2022-10-04

Abstract excerpt

Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophillike cells via suppressing Rac activation. Here, we show that in mouse embryonic fibroblasts, MFN2 suppresses RhoA activation and supports cell polarization. After the initial spreading period, the wild-type cells polarize and migrate,...

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Literature Corpus work: 8b4b4a0d-f500-5527-8784-69c5de5ba2ec
DOI: 10.1101/2022.10.03.510661

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Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cellsDOI 10.1101/2022.10.03.510661Read

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