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Article

Regulation of formin INF2 and its alteration in INF2-linked inherited disorders.

Cellular and molecular life sciences : CMLS - 25 Nov 2024

Labat-de-Hoz Leticia, Jiménez M Ángeles, Correas Isabel, Alonso Miguel A

Abstract excerpt

Formins are proteins that catalyze the formation of linear filaments made of actin. INF2, a formin, is crucial for correct vesicular transport, microtubule stability and mitochondrial division. Its activity is regulated by a complex of cyclase-associated protein and lysine-acetylated G-actin (KAc-actin), which helps INF2 adopt an inactive conformation through the association of its N-terminal diaphanous...

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Identifiers

PMID: 39586895
DOI: 10.1007/s00018-024-05499-3
PMCID: PMC11589041

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