Article
Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Molecular cell - 15 Jun 2017
Bagur Rafaela, Hajnóczky György
Abstract excerpt
Ca2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific targets depends on spatiotemporal patterning of the calcium signal and decoding it by multiple, tunable, and often strategically positioned Ca2+-sensing elements. Ca2+ is detected by specialized motifs on proteins that have been biochemically characterized...
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