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Article

Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.

Nature communications - 29 Oct 2019

Li Yu-Jie, Cao Yu-Lu, Feng Jian-Xiong, Qi Yuanbo, Meng Shuxia, Yang Jie-Feng, Zhong Ya-Ting, Kang Sisi, Chen Xiaoxue, Lan Lan, Luo Li, Yu Bing, Chen Shoudeng, Chan David C, Hu Junjie, Gao Song

Abstract excerpt

Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Mutations in MFN2 cause the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). The molecular basis underlying the physiological and pathological relevance of MFN2 is unclear. Here, we present crystal structures of truncated human MFN2 in different nucleotide-loading states....

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Identifiers

PMID: 31664033
DOI: 10.1038/s41467-019-12912-0
PMCID: PMC6820788

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