Article

Structural Basis of Lipid Membrane Binding by Human Ferlins

2025-01-27

Abstract excerpt

Ferlins, ancient membrane proteins with a unique architecture, are central to multiple essential, Ca 2+ -dependent vesicle fusion processes. Despite numerous functional studies and their link to burdening human diseases, a mechanistic understanding of how these multi-C 2 domain proteins interact with lipid membranes to promote their remodeling and fusion is currently lacking. Here, we elucidate the near-complete...

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Literature Corpus work: bea7da11-74d6-5047-bbb1-da7f36e7e9e1
DOI: 10.1101/2025.01.25.634844

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