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Article

Role of formin INF2 in human diseases.

Molecular biology reports - 1 Jan 2022

Zhao Yiting, Zhang Hui, Wang Haibiao, Ye Meng, Jin Xiaofeng

Abstract excerpt

Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomerulosclerosis and cancers, such as colorectal and thyroid cancer where it functions as a tumor suppressor,...

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Source

Identifiers

PMID: 34698992
DOI: 10.1007/s11033-021-06869-x

Genes

INF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of formin INF2 in human diseases.PMID 34698992Read ↗

The formin INF2 in disease: progress from 10 years of research.Semantic proximity Read ↗

Regulation of formin INF2 and its alteration in INF2-linked inherited disorders.Semantic proximity Read ↗

Clinical and Pathological Heterogeneity in FSGS due to INF2 MutationsSemantic proximity Read ↗

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.Semantic proximity Read ↗

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosisSemantic proximity Read ↗

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosisSemantic proximity Read ↗

INF2 mutations cause kidney disease through a gain-of-function mechanism.Semantic proximity Read ↗

A deregulated stress response underlies distinct INF2 associated disease profilesSemantic proximity Read ↗

Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis.Semantic proximity Read ↗

Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.Semantic proximity Read ↗

Inverted formins: A subfamily of atypical forminsSemantic proximity Read ↗

A Deregulated Stress Response Underlies Distinct INF2-Associated Disease Profiles.Semantic proximity Read ↗

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