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Article

α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2.

The EMBO journal - 2 Mar 2020

Turner Matthew, Anderson David E, Bartels Peter, Nieves-Cintron Madeline, Coleman Andrea M, Henderson Peter B, Man Kwun Nok Mimi, Tseng Pang-Yen, Yarov-Yarovoy Vladimir, Bers Donald M, Navedo Manuel F, Horne Mary C, Ames James B, Hell Johannes W

Abstract excerpt

The L-type Ca2+ channel CaV 1.2 governs gene expression, cardiac contraction, and neuronal activity. Binding of α-actinin to the IQ motif of CaV 1.2 supports its surface localization and postsynaptic targeting in neurons. We report a bi-functional mechanism that restricts CaV 1.2 activity to its target sites. We solved separate NMR structures of the IQ motif (residues 1,646-1,664) bound to α-actinin-1 and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31985069
DOI: 10.15252/embj.2019102622
PMCID: PMC7049811

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