Article

Genomic mosaicism reveals developmental organization of trunk neural crest-derived ganglia

2024-09-26

Abstract excerpt

<h4>Summary</h4> The neural crest generates numerous cell types, but conflicting results leave developmental origins unresolved. Here using somatic mosaic variants as cellular barcodes, we infer embryonic clonal dynamics of trunk neural crest, focusing on the sensory and sympathetic ganglia. From three independent adult neurotypical human donors, we identified 1,278 mosaic variants using deep whole-genome sequenc...

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Literature Corpus work: 658767f6-86e2-5f21-a4d9-60ad420b9d23
DOI: 10.1101/2024.09.25.615004

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