Article
Cell lineage analysis in human brain using endogenous retroelements.
Neuron - 7 Jan 2015
Evrony Gilad D, Lee Eunjung, Mehta Bhaven K, Benjamini Yuval, Johnson Robert M, Cai Xuyu, Yang Lixing, Haseley Psalm, Lehmann Hillel S, Park Peter J, Walsh Christopher A
Abstract excerpt
Somatic mutations occur during brain development and are increasingly implicated as a cause of neurogenetic disease. However, the patterns in which somatic mutations distribute in the human brain are unknown. We used high-coverage whole-genome sequencing of single neurons from a normal individual to identify spontaneous somatic mutations as clonal marks to track cell lineages in human brain. Somatic mutation...
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