Article

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

2020-03-11

Abstract excerpt

A key question in genome research is whether biologically active proteins are restricted to the ∼20,000 canonical, well-annotated genes, or rather extend to the many non-canonical open reading frames (ORFs) predicted by genomic analyses. To address this, we experimentally interrogated 553 ORFs nominated in ribosome profiling datasets. Of these 553 ORFs, 57 (10%) induced a viability defect when the endogenous ORF w...

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Literature Corpus work: 0a6b990f-6161-52bb-984a-cf231488afdd
DOI: 10.1101/2020.03.10.981001

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