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Article

Structured elements drive extensive circular RNA translation.

Molecular cell - 21 Oct 2021

Chen Chun-Kan, Cheng Ran, Demeter Janos, Chen Jin, Weingarten-Gabbay Shira, Jiang Lihua, Snyder Michael P, Weissman Jonathan S, Segal Eran, Jackson Peter K, Chang Howard Y

Abstract excerpt

The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to undergo translation without a 5' cap. Here, we develop a high-throughput screen to systematically discover RNA sequences that can direct circRNA translation in human cells. We identify more than 17,000 endogenous and synthetic sequences as...

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Identifiers

PMID: 34437836
DOI: 10.1016/j.molcel.2021.07.042
PMCID: PMC8567535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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