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An Improved Human smORF Annnotation Workflow Combining De Novo Transcriptome Assembly and Ribo-Seq

2019-01-17

Abstract excerpt

Protein-coding small open reading frames (smORFs) are emerging as an important class of genes, however, the coding capacity of smORFs in the human genome is unclear. By integrating de novo transcriptome assembly and Ribo-Seq, we confidently annotate thousands of novel translated smORFs in three human cell lines. We find that smORF translation prediction is noisier than for annotated coding sequences, underscoring...

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Literature Corpus work
164cb64f-3cfb-5b6e-9a4b-71a4596163b1
DOI
10.1101/523860
Open publication

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An Improved Human smORF Annnotation Workflow Combining De Novo Transcriptome Assembly and Ribo-SeqDOI 10.1101/523860
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