Article

Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genome

2026-08-17

Abstract excerpt

Ribosome profiling has revealed widespread translation of upstream open reading frames (uORFs) within the human 5′ untranslated region, greatly expanding the apparent coding potential of the genome. However, despite pervasive translational activity, uORF-encoded proteins (uORFps) are only rarely detected by proteomic approaches, creating a major unresolved discrepancy between translation and protein accumulation....

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Literature Corpus work: 99844613-f84f-5150-b913-2d34753645c3
DOI: 10.64898/2026.08.12.739961

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