Back to search

Article

Exploring the Dark Matter of Human Proteome: Emerging Role of Non-canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and Therapy

2024-06-28

Abstract excerpt

Cancer develops from abnormal cell growth in the body, causing significant mortalities every year. To date, potent therapeutic approaches have been developed to eradicate tumor cells, but intolerable toxicity and drug resistance can occur in treated patients, limiting the efficiency of existing treatment strategies. Therefore, searching for novel genes critical for cancer progression and therapeutic response is ur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bcf2ccd8-b086-5c32-a122-2617028aefe9
DOI
10.20944/preprints202406.2031.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Exploring the Dark Matter of Human Proteome: Emerging Role of Non-canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and TherapyDOI 10.20944/preprints202406.2031.v1
Exploring the Dark Matter of Human Proteome: The Emerging Role of Non-Canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and TherapySemantic proximity
Beyond the Genome: Microproteins Unveiling New Dimensions in CancerSemantic proximity
CrypticProteinDB: an integrated database of proteome and immunopeptidome derived non-canonical cancer proteinsSemantic proximity
The microproteome of cancer: From invisibility to relevanceSemantic proximity
High-quality peptide evidence for annotating non-canonical open reading frames as human proteinsSemantic proximity
Open reading frames associated with cancer in the dark matter of the human genome.Semantic proximity
Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancerSemantic proximity
Proteogenomics analysis of non-coding region encoded peptides in normal tissues and five cancer typesSemantic proximity
Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigensSemantic proximity
A deep audit of the PeptideAtlas database uncovers evidence for unannotated coding genes and aberrant translationSemantic proximity
Discovery of evolutionarily extended <i>cis</i> -regulatory overlapping genes expanding the protein universe from animals to humansSemantic proximity
Some like it translated: small ORFs in the 5′UTRSemantic proximity
Select a neighboring publication to make it the new centre.