Article

Contextual diversity of the human cell-essential proteome

2017-02-10

Abstract excerpt

Essential genes define central biological functions required for cell growth, proliferation and survival, but the nature of gene essentiality across human cell types is not well understood. We assessed essential gene function in a Cas9-inducible human B-cell lymphoma cell line using an extended knockout (EKO) library of 278,754 sgRNAs that targeted 19,084 RefSeq genes, 20,852 alternatively-spliced exons and 3,872...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 157e8312-311d-5d6b-9e2e-974489307fee
DOI: 10.1101/107797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contextual diversity of the human cell-essential proteomeDOI 10.1101/107797Read

Systematic discovery and classification of human cell line essential genesSemantic proximity Read

Human gene essentiality.Semantic proximity Read

New insights on human essential genes based on integrated analysisSemantic proximity Read

Assessing tissue-specific gene expression of essential genes from human and mouseSemantic proximity Read

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.Semantic proximity Read

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout ScreensSemantic proximity Read

Genetic mechanisms for tissue-specific essential genesSemantic proximity Read

Ranking of non-coding pathogenic variants and putative essential regions of the human genome.Semantic proximity Read

Comprehensive prediction and analysis of human protein essentiality based on a pre-trained protein large language modelSemantic proximity Read

In vivo and in vitro human gene essentiality estimations capture contrasting functional constraintsSemantic proximity Read

CEN-tools: an integrative platform to identify the contexts of essential genes.Semantic proximity Read

A single-gene-based AI model to identify core and context-specific essential genes by biological interpretation from pooled genome-wide CRISPR and omics dataSemantic proximity Read