Article

Discovery of evolutionarily extended <i>cis</i> -regulatory overlapping genes expanding the protein universe from animals to humans

2025-07-31

Abstract excerpt

A recent proteogenomics-driven approach has uncovered actively translated alternative open reading frames (altORFs) that complement reference protein-coding sequences (refCDSs). Here, we further explored proteogenomic data to identify hidden proteomes, specifically short ORF-encoded polypeptides (SEPs) and longer altORF-encoded proteins (LEPs) previously overlooked in human genomes. We discovered a novel class of...

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Literature Corpus work: fcb361f0-88e0-536e-853b-3d79963e4b87
DOI: 10.1101/2025.07.27.667088

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