Article

A single-gene-based AI model to identify core and context-specific essential genes by biological interpretation from pooled genome-wide CRISPR and omics data

2024-11-03

Abstract excerpt

Genome-wide Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a powerful tool for screening essential genes (EGs) and studying gene function by systematically knocking out individual genes. EGs are essential for the survival of organisms and can be divided into core EGs (CEGs) and context-specific EGs, which are crucial for the development of drugs. Although a variety of CEGs have been identifi...

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Literature Corpus work: a47cf414-ddc8-5388-bee9-3c1b60a022c1
DOI: 10.1101/2024.11.03.621717

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