CrypticProteinDB: an integrated database of proteome and immunopeptidome derived non-canonical cancer proteins

Abstract excerpt

Translated non-canonical proteins derived from noncoding regions or alternative open reading frames (ORFs) can contribute to critical and diverse cellular processes. In the context of cancer, they also represent an under-appreciated source of targets for cancer immunotherapy through their tumor-enriched expression or by harboring somatic mutations that produce neoantigens. Here, we introduce the largest...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Peptidase Inhibition and Analysis
• Share to RNA and protein synthesis mechanisms
• Share to vaccines and immunoinformatics approaches