Article

High-throughput proteo-genomic identification of functional endothelial cell microproteins encoded by non-canonical small open reading frames

2024-04-09

Abstract excerpt

<title>Abstract</title> <p>Detecting microproteins (miPs) translated from small open reading frames (smORFs) by mass spectrometry poses major challenges. Here we report a high-throughput proteo-genomic pipeline that identified a large number of intracellular and extracellular endothelial cell miPs encoded by non-canonical smORFs. Vascular inflammation in vitro and in vivo profoundly altered smORF expression and m...

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Literature Corpus work: d59e00a3-5fa6-5533-8da9-fbf5840cf273
DOI: 10.21203/rs.3.rs-4194943/v1

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