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Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and <i>APOE</i> -related immunometabolic pathway perturbations

2021-05-16

Abstract excerpt

Microglia have fundamental roles in health and disease, however effects of age, sex and genetic factors on human microglia have not been fully explored. We applied bulk and single cell approaches to comprehensively characterize human microglia transcriptomes and their associations with age, sex and APOE . We identified a novel microglial signature, characterized its expression in bulk tissue and single cell micro...

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Literature Corpus work
aadbd29f-9eff-5837-8980-cf787cdec76c
DOI
10.1101/2021.05.13.444000
Open publication

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Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and <i>APOE</i> -related immunometabolic pathway perturbationsDOI 10.1101/2021.05.13.444000
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