Article

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human Microglia

2026-05-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> ApoE4 is the strongest genetic risk factor for Alzheimer’s disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. <h4>Methods</h4> Human microglia were treated with lipid-free or lipid-bound ApoE3 or ApoE4...

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Literature Corpus work: 519ff54a-7dad-59ac-960a-da50e836e297
DOI: 10.64898/2026.05.04.722733

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