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Article

Human microglia show unique transcriptional changes in Alzheimer’s disease

29 May 2023

Abstract excerpt

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD) progression and are potential therapeutic targets. However, microglia exhibit diverse functions, the regulation of which is not fully understood, complicating therapeutics development. To better define the transcriptomic phenotypes and gene regulatory networks associated with AD, we enriched for microglia nuclei from 12 AD and 10...

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PMID: 37248328
DOI: 10.1038/s43587-023-00424-y

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