Article

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

2023-07-25

Abstract excerpt

Several genetic risk factors for Alzheimer’s Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Through single-nucleus RNA-sequencing of AD brain tissue, we have identified a microglial state defined by the expression of the lipid droplet (...

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Literature Corpus work: 90cc35e6-46bb-53d3-ad26-0c903e1910fa
DOI: 10.1101/2023.07.21.549930

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