Article

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer’s Disease

2025-05-16

Abstract excerpt

Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-driving) microglial heterogeneity. However, our understanding of how proximity to these Alzheimer’s disease (AD) pathological hallmarks in situ relates to microglial gene expression remains obscure. Here, we utilized hi...

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Literature Corpus work: 708addff-1e6e-578c-8bce-64d36ac479e0
DOI: 10.1101/2025.05.16.654329

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High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer’s DiseaseDOI 10.1101/2025.05.16.654329Read

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