Article

Metabolic Transcriptional Heterogeneity in Human Microglia Across the Alzheimer's Disease Pathological Continuum: A Donor-Aware Analysis of the SEA-AD Atlas

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>Microglia occupy diverse inflammatory and lipid-processing states in Alzheimer's disease (AD), but whether broad metabolic transcriptional programs vary mainly by cell state or track regional neuropathological burden remains unclear. We analyzed the open Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) multiregion single-nucleus RNA-sequencing immune dataset, comprising 240,651 imm...

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Literature Corpus work: a677a80f-d777-56d9-8e87-aad4fd9bafd0
DOI: 10.21203/rs.3.rs-10618897/v1

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