Article

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology

2021-07-20

Abstract excerpt

To better define roles that astrocytes and microglia play in Alzheimer’s disease (AD), we used single-nuclei RNA sequencing to comprehensively characterize transcriptomes in astrocyte and microglia nuclei isolated post mortem from neuropathologically-defined AD and control brains with a range of amyloid-beta and phospho-tau (pTau) pathology. Significant differences in glial gene expression (including AD risk gene...

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Literature Corpus work: 4aa56ec2-ae77-51ac-8ca4-cf33a56f7989
DOI: 10.1101/2021.07.19.452932

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