Article
Cell-type signatures of Alzheimer's disease shared across population groups.
Nature - 1 Sept 2026
Luquez Tain, Algoo Jonathan, Chiu Rebecca, Mares Jason A, Yadav Archana, Lam Matti, Gaur Pallavi, Lai Xiaoying, Lee Dylan I, Paryani Fahad, Batchelor Rafe, Belli Irla, Henry Jordan, Hoter-Ishay Bat, Mattison Courteney, Starr Lindsey, Lama Tsering, Karaahmet Berke, Cao Wenqing, De Jager Philip L, Taga Mariko, Barnes Lisa L, Marquez David X, Bennett David A, Zhang Ya, Menon Vilas
Abstract excerpt
Genomic studies at single-cell resolution have identified several cell types associated with clinical and pathological traits in Alzheimer's disease1-9, but have not examined associations that are shared across populations. To bridge this gap, here we use single-nucleus RNA sequencing and assay for transposase-accessible chromatin with sequencing to profile cortical and subcortical regions in post-mortem...
Read the complete abstract on PubMedTopics
- Female
- Humans
- Male
- Alzheimer Disease
- Astrocytes