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Topoisomerase I in Human Disease Pathogenesis and Treatments

12 May 2016

Abstract excerpt

Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell growth. Unfortunately, this exact activity can covalently trap TOP1 on the DNA that could lead to cell death or mutagenesis, a precursor for tumorigenesis. It is therefore important for cells to...

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PMID: 27181710
DOI: 10.1016/j.gpb.2016.02.004

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