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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

13 Jun 2025

Abstract excerpt

Topoisomerase II (TOP2) inhibitors (TOP2i) are mainstay chemotherapeutic agents that undermine genome integrity by stabilizing TOP2-DNA complexes accompanied by DNA damage formation. Here, we reveal the uncharacterized protein CRAMP1 and H1 linker histones as key effectors of TOP2i tolerance in human cells. We demonstrate that CRAMP1 defines a dedicated histone H1 biogenesis factor stimulating transcription of...

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PMID: 40516529
DOI: 10.1016/j.molcel.2025.04.006

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